Main Research Interests
My main research interests involve studying the genetic basis of adaptation to the laboratory by monitoring the dynamics at the genomic level in replicated populations of Drosophila subobscura since foundation from the wild. In that sense, I am characterizing microsatellites and inversions polymorphism as well as gene expression changes through time from a former to a later generation in the lab. At the same time, I intend to relate the evolution at the genomic level with the dynamics of phenotypic traits more or less closely related to fitness. With this study, our group aims to understand the response at the genetic level of populations adapting to a new environment and mostly clarify the role played by selection vs. genetic drift in the process of adaptation.
- 2004 Degree in Biology (University of Lisbon)
Bárbaro M., Mira M. S., Fragata I., Simões P., Lima M., Lopes-Cunha M., Kellen B., Santos J., Varela S.A.M., Matos M.* & Magalhães S.* 2015. Evolution of mating behavior between two populations adapting to common environmental conditions. Ecology and Evolution 5(8):1609–1617 [* joint last authors]
Matos M., Simões P., Santos M.A., Seabra S.G., Faria G.S., Vala F., Santos J. & Fragata I. 2015. History, chance and selection during phenotypic and genomic experimental evolution: replaying the tape of life at different levels. Front. Gene. 6:71. doi: 10.3389/fgene.2015.00071
Fragata I., Simões P., Lopes-Cunha M., Lima M., Kellen B., Bárbaro M., Santos J., Rose M. R., Santos M. & Matos M. 2014. Laboratory Selection Quickly Erases Historical Differentiation. PLoS ONE 9(5):e96227.
Santos J., Pascual M., Simões P., Fragata I., Rose M.R. & Matos M. 2013. Fast evolutionary genetic differentiation during experimental colonizations. Journal of Genetics 92(2):183-194.
Santos J., Pascual M., Simões P., Fragata I., Lima M., Kellen B., Santos M., Marques A., Rose M.R. & Matos M. 2012. From nature to the lab: the impact of founder effects on adaptation. Journal of Evolutionary Biology 25:2607-2622.
Santos M., Fragata I., Santos J., Simões P., Marques A., Lima M. & Matos M. 2010. Playing Darwin. Part B. 20 years of domestication in Drosophila subobscura. Theory in Biosciences 129(2/3):97-102.
Santos J., Serra L., Solé E. & Pascual M. 2010. FISH mapping of microsatellite loci from Drosophila subobscura and its comparison to related species. Chromosome Research 18(2):213-226.
Simões P., Santos J. & Matos M. 2009. Experimental Evolutionary Domestication. In: Experimental Evolution: Concepts, Methods, and Applications of Selection Experiments. Garland, T. & Rose M. R. (eds.), California University Press, pp. 89-110.
Simões P., Pascual M., Santos J., Rose M.R. & Matos M. 2008. Evolutionary dynamics of molecular markers during local adaptation: A case study in Drosophila subobscura. BMC Evolutionary Biology 8:66.
Simões P., Santos J., Fragata I., Mueller L.D., Rose M.R. & Matos M. 2008. How repeatable is Adaptive Evolution? The role of geographical origin and founder effects in laboratory adaptation. Evolution 62(8):1817-1829.
The genetic basis of adaptation to captivity: the Drosophila subobscura model (PTDC/BIA-BDE/65733/2006) (team member)